Research
The evidence is growing-
There are 100s of studies out there, exploring the wide applications for methylene bliue. Below you will find the headings of a handful of these studies. We have taken extracts from each studies conclusion, to save you some time. Click the link below each one if you wish to delve deeper.
From Mitochondrial Function to Neuroprotection-an Emerging Role for Methylene Blue.
The excellent safety record of MB is well established by a century of medical use. Its newly explored role as a mitochondrial enhancer and recycling antioxidant is key to its potential as a therapeutic agent. With encouraging results in preclinical trials of some of the most disabling neurodegenerative conditions, MB should be investigated with renewed enthusiasm in years to come.
The Potentials of Methylene Blue as an Anti-Aging Drug.
Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue.
Together, these studies provide conclusive evidence that low doses of pharmaceutical grade (USP) MB are effective for improving different forms of memory and for preventing various neurochemical, structural, and functional deficits derived from mitochondrial inhibition and oxidative stress.
Article on exsisting studies of MB on Malaria.
In conclusion, the findings from the existing studies clearly demonstrate the efficacy and safety of MB in the treatment of malaria. While there is a need to conduct more clinical studies on the effects of MB in P. vivax malaria, there is already high evidence for strong effects of the drug against the parasites of P. falciparum,
The use of methylene blue in adult patients with septic shock: a systematic review and meta-analysis
Additionally, methylene blue is likely associated with improvement in the PaO2/FiO2 ratio, as well as reductions in mortality rate, serum lactate levels, and length of hospital stay.
Clinical effectiveness and prospects of methylene blue: A systematic review.
MB is known for its accessibility, extensive safety profile, and proven versatility and has been used in medicine for decades. The studies included in the present review did not identify any potentially lethal side effects of PDT, suggesting that it is a safe procedure for treating mild infections if performed under supervision.
Acsorbate acid with Methylene Blue.
Below a few pieces on Leucomethylene. Leucomethylene is a combination of ascobic acid and Methylene blue. It aids in uptake of vitamin C, and has the added benefit of reducing the blue staining of Methylene blue. See the Riodan clinic videos for more infomation.
Note.
Ascorbic acid has a very short shelf life and degrades significantly even in dark and cool conditions. The only way to stop this is by adding additional preservative compounds.. Its very easy to make at home, and ascobic acid is realatively easy to find.
Stability of aqueous solutions of ascorbate for basic research and for intravenous administration
Ascorbate (vitamin C) can rapidly oxidize in many near-neutral pH, aqueous solutions. We report on the stability of ascorbate solutions prepared for infusion into patients using standard pharmacy protocols, for example, 75 g of ascorbate/L in water for infusion. The concentration of ascorbate was monitored for changes over time using direct UV–Vis spectroscopy. The pH of the solution was about 5.7 with no significant change over 24 h. There was only an approximate loss of 1% per day over the first 3 days of storage.
How Methylene Blue’s Antioxidants Can Slow Cognitive Decline
Methylene Blue and vitamin C have a special synergy in the body – a kind of give-and-take that assists in maintaining healthy cellular energy.
Ascorbic acid is the reduced form of vitamin C. On the other hand, the dark blue methylene dye is an oxidized form. When the two are combined, it creates a clear liquid form called leukoMethylene Blue with increased antioxidant power. Antioxidants are molecules that “put out the fire of oxidation,” thereby reducing oxidative stress and its resulting damage at the cellular level.
A cohort of cancer patients with no reported cases of SARS-CoV-2 infection : the possible preventive role of Methylene Blue
Leuco-methylene blue (LMBH) quickly crosses the blood-brain barrier and at daily dose of 15 mg is a MAO-A inhibitor boosting serotonin (5-HT) and increasing levels of catecholamines in the brain with thus reduced anxiety and depression and concomitant improvement of memory (increased levels of Ach) and mood.
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